A Role for Natural Regulatory T Cells in the Pathogenesis of Experimental Cerebral Malaria
نویسندگان
چکیده
منابع مشابه
Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria.
Cerebral malaria (CM) associated with Plasmodium berghei ANKA (PbA) infection is an accepted model of human CM. CM during PbA infection critically depends on sequestration of T cells into the brain. Several studies aimed to address the role of regulatory T cells (T(reg)) in modulating this pathogenic T cell response. However, these studies are principally hampered due to the fact that until rec...
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Studies in malaria patients indicate that higher frequencies of peripheral blood CD4(+) Foxp3(+) CD25(+) regulatory T (Treg) cells correlate with increased blood parasitemia. This observation implies that Treg cells impair pathogen clearance and thus may be detrimental to the host during infection. In C57BL/6 mice infected with Plasmodium berghei ANKA, depletion of Foxp3(+) cells did not improv...
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Affi liations: From the Department of Pulmonary and Critical Care Medicine (Dr O’Donnell), the Department of Radiology (Dr Bankier), and the Department of Anesthesia and Critical Care (Dr Loring), Beth Israel Deaconess Hospital; the Department of Pulmonology (Dr Stiebellehner), Medical University of Vienna; Pulmonary and Critical Care Medicine (Dr Reilly) Brigham and Women’s Hospital; and the P...
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Plasmodium falciparum malaria causes 500 million clinical cases with approximately one million deaths each year. After many years of exposure, individuals living in endemic areas develop a form of clinical immunity to disease known as premunition, which is characterised by low parasite burdens rather than sterilising immunity. The reason why malaria parasites persist under a state of premunitio...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2007
ISSN: 0002-9440
DOI: 10.2353/ajpath.2007.061033